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PACCM Scientific Review Process

What is the purpose of the PACCM departmental scientific review?

The purpose of the scientific review is to ensure that research proposals reflect an acceptable level of scientific rigor and merit prior to ethical review. Through the scientific review process we ensure that the study is well-designed, has a valid research hypothesis, objectives, appropriate balance between the potential risks and benefits, and has adequate resources so that we do not expose research subjects to unnecessary harms. The scientific review process also offers the Division of PACCM an opportunity to improve the quality of pulmonary research and to facilitate mentoring of junior researchers, identification of synergies among related lines of investigation, and knowledge of current research that can support plans for Division growth.

Which research studies need scientific review?

All pulmonary-based research protocols except for those that have already undergone a scientific review as a condition of funding (e.g., NIH-funded research) or are determined not to require a scientific review (e.g., exempt research).

Who perform the PACCM departmental scientific review?

Rama K. Mallampalli, MD and Joseph M. Pilewski, MD (primary reviewer) are the designated PACCM departmental scientific reviewers. If Dr. Mallampalli or Dr. Pilewski is a member of the study team or does not have the expertise to review a study, another individual will be assigned to conduct the review.

What paperwork is required for the PACCM departmental scientific review?

Research studies submitted to Pitt IRB – OSIRIS system: No additional paperwork is required. As soon as the PI submits the study for review, both Dr. Mallampalli & Dr. Pilewski will receive an e-mail notification to conduct the review and issue scientific approval.

Research studies submitted to UPMC OSPARS (e.g. Industry initiated research studies): The PI or the study team is required to provide as much information as possible to facilitate the scientific review. Incomplete information may slow down the review and approval process.

**Submit the scientific request to Dr. Pilewski (pilewskijm@upmc.edu) or Dr. Mallampalli (mallampallirk@upmc.edu) and attach the following required documents in the e-mail request: